Sectional A
 @ Beecher HS Softball Field
 | 
| 
Date: Saturday, September 18, 2021
 | 
| 
Beecher def. Braidwood Reed-Custer
, 9-0
 in 7 innings
 | 
Beecher record now  22-0-0
 | 
Sectional B
 @ Wenona City Park
 | 
| 
Date: Saturday, September 18, 2021
 | 
| 
Metamora GS def. Ottawa Marquette
, 13-3
 in 6 innings
 | 
Metamora GS record now  19-2-0
 | 
Sectional C
 @ Illini Bluffs Softball Diamonds
 | 
| 
Date: Saturday, September 18, 2021
 | 
| 
Glasford Illini Bluffs def. Joy Mercer County
, 2-1
 in 8 innings
 | 
Glasford Illini Bluffs record now  19-0-0
 | 
Sectional D
 @ Le Roy Elementary School
 | 
| 
Date: Saturday, September 18, 2021
 | 
| 
Westville JHS def. Downs Tri-Valley
, 13-3
 in 6 innings
 | 
Westville JHS record now  18-1-0
 | 
Sectional E
 @ Fairfield Park
 | 
| 
Date: Saturday, September 18, 2021
 | 
| 
Robinson Nuttall def. Newton Jasper County
, 11-0
 in 5 innings
 | 
Robinson Nuttall record now  16-1-0
 | 
Sectional F
 @ Maroa Park
 | 
| 
Date: Saturday, September 18, 2021
 | 
| 
Shelbyville Moulton def. Maroa-Forsyth
, 5-4
 in 7 innings
 | 
Shelbyville Moulton record now  18-1-0
 | 
Sectional G
 @ Ben-Gil Elementary School
 | 
| 
Date: Saturday, September 18, 2021
 | 
| 
Gillespie def. New Berlin JHS
, 7-5
 in 7 innings
 | 
Gillespie record now  18-1-0
 | 
Sectional H
 @ Central School
 | 
| 
Date: Saturday, September 18, 2021
 | 
| 
Athens def. Rushville Schuyler Industry
, 3-2
 in 7 innings
 | 
Athens record now  15-5-0
 |