| Sectional 1 @ Grand Ridge |
| Grand Ridge vs. Ottawa Wallace (17-3) |
| Regional 1 | Grand Ridge def. Mazon-Verona-Kinsman, 30-17 |
| Regional 2 | Ottawa Wallace def. LaSalle Trinity Catholic, 38-19 |
| Sectional 2 @ Cissna Park |
| Rantoul St. Malachy (17-3) vs. Streator Woodland (3-11) |
| Regional 3 | Rantoul St. Malachy def. St. Anne, 15-7 |
| Regional 4 | Streator Woodland def. Pontiac St. Mary's, 31-30 |
| Sectional 3 @ London Mills Valley |
| Bartonville Monroe (19-2) vs. London Mills Valley (16-6) |
| Regional 5 | Bartonville Monroe def. Washington St. Patrick, 26-7 |
| Regional 6 | London Mills Valley def. Peoria Limestone Walters, 50-24 |
| Sectional 4 @ Hume Shiloh |
| Hume Shiloh (14-5) vs. Armstrong-Ellis (17-4) |
| Regional 7 | Hume Shiloh def. Rossville-Alvin, 26-23 |
| Regional 8 | Armstrong-Ellis def. Royal Prairieview Ogden, 31-24 |
| Sectional 5 @ Springfield Calvary |
| Decatur Holy Family (13-3) vs. Springfield Calvary (17-3) |
| Regional 9 | Decatur Holy Family def. Decatur St. Patrick, 38-20 |
| Regional 10 | Springfield Calvary def. Springfield Christian, 31-21 |
| Sectional 6 @ Effingham Sacred Heart |
| Dieterich vs. Sigel St. Michael's (16-1) |
| Regional 11 | Dieterich def. Effingham Sacred Heart, 33-30 |
| Regional 12 | Sigel St. Michael's def. Beecher City, 33-18 |
| Sectional 7 @ Carrollton St. John |
| Pocahontas vs. Jerseyville St. Francis HG (13-5) |
| Regional 13 | Pocahontas def. Divernon, 32-30 |
| Regional 14 | Jerseyville St. Francis HG def. Hardin St. Norbert, 34-32 |
| Sectional 8 @ Virginia |
| Jacksonville Our Saviour vs. Meredosia-Chambersburg (9-8) |
| Regional 15 | Jacksonville Our Saviour def. Concord Triopia, - |
| Regional 16 | Meredosia-Chambersburg def. Griggsville-Perry, 24-21 |
