| Sectional 1 @ Milford |
| Milford vs. Colfax-Ridgeview (16-7) |
| Regional 2 |
Colfax Ridgeview def. Pontiac St. Mary 39-25 |
| Sectional 2 @ Effingham Sacred Heart |
| Effingham Sacred Heart (13-6) vs. Dieterich (11-6) |
| Regional 3 |
Effingham Sacred Heart def. Sigel St. Michael's 26-23 |
| Regional 4 |
Dieterich def. Noble West Richland 19-11
|
| Sectional 3 @ Fox River Grove |
| Fox River Grove (18-1) vs. Beecher (15-1) |
| Regional 5 |
Fox River Grove def. Ford Heights Cottage Grove 45-14 |
| Regional 6 |
Beecher def. South Wilmington 40-10
|
| Sectional 4 @ Cuba |
| Cuba (18-3) vs. Brimfield (16-2) |
| Regional 7 |
Cuba def. Table Grove V.I.T. 46-14 |
| Regional 8 |
Brimfield def. Hanna City Logan 29-22
|
| Sectional 5 @ Jerseyville St. Francis-Holy Ghost |
| Jerseyville St. Francis-Holy Ghost (10-5) vs. Mt. Olive (9-10) |
| Regional 9 |
Jerseyville St. Francis-Holy Ghost def. Greenfield 53-35 |
| Regional 10 |
Mt. Olive def. Bunker Hill Meissner 32-18
|
| Sectional 6 @ Chandlerville A-C Central |
| Jacksonville Our Saviour (14-0) vs. Springfield Christian (9-9) |
| Regional 11 |
Jacksonville Our Saviour def. Chandlerville A-C Central 28-26 |
| Regional 12 |
Springfield Christian def. Sprinfield St. Aloysious 17-9
|
| Sectional 7 @ Washington St. Patrick |
| Bloomington Holy Trinity vs. Flanagan (16-4) |
| Regional 13 |
Bloomington Holy Trinity def. Normal Epiphany 49-12 |
| Regional 14 |
Flanagan def. Roanoke-Benson 41-28
|
| Sectional 8 @ Mazon-Verona-Kinsman |
| Ottawa Wallace (13-5) vs. Tonica (13-1) |
| Regional 15 |
Ottawa Wallace def. Morris Saratoga 25-19 |
| Sectional 9 @ Glasford Illini Bluffs |
| Glasford Illini Bluffs (19-2) vs. Peoria Pleasant Valley (15-4) |
| Regional 17 |
Glasford Illini Bluffs def. South Pekin 46-18 |
| Regional 18 |
Peoria Pleasant Valley def. Peoria Norwood 20-16
|
| Sectional 10 @ Cissna Park |
| Cissna Park (17-3) vs. Gifford |
| Regional 19 |
Cissna Park def. Bismarck-Henning 39-11 |
| Regional 20 |
Gifford def. Rantoul St. Malachy 33-15
|
| Sectional 11 @ Hamilton |
| Carthage vs. La Harpe (18-5) |
| Regional 22 |
La Harpe def. Media Southern 31-16
|
| Sectional 12 @ Winchester |
| Winchester (16-4) vs. Griggsville/Perry (16-0) |
| Regional 23 |
Winchester def. Bluffs 26-19 |
| Sectional 13 @ Sprinfield Christ the King |
| Springfield St. Agnes (19-0) vs. Pana Sacred Heart (10-8) |
| Regional 25 |
Springfield St. Agnes def. Springfield Christ the King 39-17 |
| Regional 26 |
Pana Sacred Heart def. Nokomis South 29-23
|
| Sectional 14 @ West Lincoln-Broadwell |
| Mt. Pulaski vs. Cerro Gordo (9-11) |
| Regional 27 |
Mt. Pulaski def. West Lincoln-Broadwell 31-14 |
| Regional 28 |
Cerro Gordo def. Bement 30-8
|
| Sectional 15 @ Hume Shiloh |
| Paris Crestwood (17-3) vs. Arcola (16-4) |
| Regional 29 |
Paris Crestwood def. Martinsville 32-24 |
| Regional 30 |
Arcola def. Arthur 33-22
|
| Sectional 16 @ Mansfield Blue Ridge |
| Royal Prairieview (19-2) vs. Mansfield Blue Ridge (15-7) |
| Regional 31 |
Royal Prairieview def. Homer Heritage 48-16 |
| Regional 32 |
Mansfield Blue Ridge def. Champaign St. Matthew 20-15 |
