| Sectional 1 @ Chandlerville A-C Central |
| Jacksonville Our Saviour (6-11) vs. Springfield Christian |
| Regional 1 |
Jacksonville Our Saviour def. Concord Triopia 32-20
|
| Sectional 2 Farmington Chapman |
| Farmington Chapman (15-1) vs. Princeville |
| Regional 3 |
Farmington Chapman def. London Mills Spoon River 42-41
|
| Sectional 3 @ Champaign Judah |
| Catlin (16-2) vs. Champaign St. Matthew (14-7) |
| Regional 5 |
Catlin def. Ogden 24-23 |
| Regional 6 |
Champaign St. Matthew def. Philo St. Thomas 29-27
|
| Sectional 4 @ Chester-East Lincoln |
| Chester-East Lincoln (14-7) vs. LeRoy |
| Regional 7 |
Chester-East Lincoln def. Carroll Catholic 25-22 |
| Regional 8 |
LeRoy def. Deland-Weldon 41-36
|
| Sectional 5 @ Fox River Grove |
| Fox River Grove vs. Beecher |
| Regional 9 |
Fox River Grove def. Joliet Laraway 36-30
|
| Sectional 6 @ Cowden-Herrick |
| Nokomis South (14-4) vs. Springfield Blessed Sacrament |
| Regional 11 |
Nokomis South def. Cowden-Herrick 31-29 |
| Regional 12 |
Springfield Blessed Sacrament def. Springfield St. Agnes 42-33
|
| Sectional 7 @ Jerseyville |
| Jerseyville St. Francis-Holy Ghost (18-2) vs. Mt. Olive (17-2) |
| Regional 13 |
Jerseyville St. Francis-Holy Ghost def. Greenfield 52-20 |
| Regional 14 |
Mt. Olive def. Bunker Hill Meissner 38-19
|
| Sectional 8 @ Peoria Heights GS |
| Peoria Norwood vs. Glasford Illini Bluffs (14-7) |
| Regional 15 |
Peoria Norwood def. Peoria Heights GS 26-20 |
| Regional 16 |
Glasford Illini Bluffs def. South Pekin 46-29
|
| Sectional 9 @ Paris Crestwood |
| Paris Crestwood vs. Arthur (8-11) |
| Regional 17 |
Paris Crestwood def. Sidell Jamaica 46-20 |
| Regional 18 |
Arthur def. Atwood-Hammond 34-13
|
| Sectional 10 @ Bluffs |
| Kampsville Calhoun (18-2) vs. Bowen Southeastern (16-4) |
| Regional 19 |
Kampsville Calhoun def. Bluffs 42-31 |
| Regional 20 |
Bowen Southeastern def. Griggsville-Perry 24-21
|
| Sectional 11 @ Beecher City |
| Beecher City (20-0) vs. Dieterich (13-7) |
| Regional 21 |
Beecher City def. Sigel St. Michael 45-23 |
| Regional 22 |
Dieterich def. Clay City 47-29
|
| Sectional 12 @ Piper City Tri-Point |
| Buckley St. John's vs. Piper City Tri-Point (18-3) |
| Regional 24 |
Piper City Tri-Point def. Pontiac St. Mary's 43-31
|
| Sectional 13 @ Bloomington Holy Trinity |
| Normal Metcalf vs. Toluca Fieldcrest West (18-2) |
| Regional 26 |
Toluca Fieldcrest West def. Flanagan 39-35 (OT)
|
| Sectional 14 @ Mazon-Verona-Kinsman |
| Mazon-Verona-Kinsman vs. Streator Woodland (9-12) |
| Regional 27 |
Mazon-Verona-Kinsman def. Ransom 24-15 |
| Regional 28 |
Streator Woodland def. Grand Ridge 44-34
|
| Sectional 15 @ Media Southern |
| Media Southern (16-3) vs. Carthage (16-3) |
| Regional 29 |
Media Southern def. Roseville 29-16 |
| Regional 30 |
Carthage def. Hamilton 38-22
|
| Sectional 16 @ Fisher |
| Fisher (22-0) vs. Cissna Park (16-6) |
| Regional 31 |
Fisher def. Rantoul St. Malachy 49-12 |
| Regional 32 |
Cissna Park def. Rossville 34-10
|
