| Sectional 1 @ Jane Addams MS, Bolingbrook |
| Arlington Heights South (17-1) vs. Bolingbrook Humphrey (12-7) |
| Regional 1 | Arlington Heights South def. Bellwood Roosevelt, 37-34 |
| Regional 2 | Bolingbrook Humphrey def. Bolingbrook Jane Addams, 51-40 |
| Sectional 2 @ Chicago Longwood |
| Dolton Lincoln (15-2) vs. Markham Prairie-Hills (18-3) |
| Regional 3 | Dolton Lincoln def. Dolton Roosevelt, 55-24 |
| Regional 4 | Markham Prairie-Hills def. Harvey Brooks, 67-56 |
| Sectional 3 @ Bourbonnais UGC |
| Park Forest Forest Trail (16-0) vs. Bourbonnais UGC (19-1) |
| Regional 5 | Park Forest Forest Trail def. Ford Heights Cottage Grove, 85-57 |
| Regional 6 | Bourbonnais UGC def. Herscher Limestone, 45-26 |
| Sectional 4 @ Mokena JHS, Mokena |
| Country Club Hills Southwood (18-1) vs. Joliet Gompers (17-3) |
| Regional 7 | Country Club Hills Southwood def. New Lenox Liberty, 49-39 |
| Regional 8 | Joliet Gompers def. Romeoville Martinez, 63-57 |
| Sectional 5 @ Channahon JHS, Channahon |
| Channahon (21-1) vs. Ottawa Shepherd (20-1) |
| Regional 9 | Channahon def. Wilmington Stevens, 49-16 |
| Regional 10 | Ottawa Shepherd def. McNabb Putnam County, 38-27 |
| Sectional 6 @ G.C.M.S. MS, Gibson City |
| Paxton-Buckley-Loda (14-4) vs. Bloomington JHS (22-0) |
| Regional 11 | Paxton-Buckley-Loda def. Onarga Iroquois West, 37-22 |
| Regional 12 | Bloomington JHS def. Normal Parkside, 57-40 |
| Sectional 7 @ Central GS, Washington |
| Washington Central (21-0) vs. Stanford Olympia (17-4) |
| Regional 13 | Washington Central def. Eureka, 38-31 |
| Regional 14 | Stanford Olympia def. East Peoria Central, 34-21 |
| Sectional 8 @ Central JHS, Farmington |
| Mossville (17-4) vs. Pekin Broadmoor (17-5) |
| Regional 15 | Mossville def. Dunlap MS, 50-43 |
| Regional 16 | Pekin Broadmoor def. Farmington Central, 54-51 |
| Sectional 9 @ West Prairie MS, Colchester |
| Macomb (15-4) vs. Quincy (15-5) |
| Regional 17 | Macomb def. Aledo, 50-27 |
| Regional 18 | Quincy def. Pittsfield Pikeland, 54-26 |
| Sectional 10 @ Mary Miller JHS, Georgetown |
| Danville North Ridge (14-6) vs. Champaign Jefferson (20-1) |
| Regional 19 | Danville North Ridge def. Westville JHS, 56-53 |
| Regional 20 | Champaign Jefferson def. Champaign Franklin, 78-62 |
| Sectional 11 @ Tolono Unity |
| Tolono Unity vs. Heyworth (13-8) |
| Regional 21 | Tolono Unity def. Mahomet-Seymour, 42-25 |
| Regional 22 | Heyworth def. Maroa-Forsyth, 38-36 |
| Sectional 12 @ Riverton MS, Riverton |
| Decatur Stephen Decatur vs. Springfield Jefferson (15-6) |
| Regional 23 | Decatur Stephen Decatur def. Mt. Zion, 49-35 |
| Regional 24 | Springfield Jefferson def. Rochester, 44-35 |
| Sectional 13 @ Havana JHS, Havana |
| Springfield Franklin (19-1) vs. Chatham Glenwood |
| Regional 25 | Springfield Franklin def. Springfield Grant, 59-18 |
| Regional 26 | Chatham Glenwood def. Jacksonville Turner, 46-33 |
| Sectional 14 @ Charleston MS, Charleston |
| Charleston (19-1) vs. Marshall JHS |
| Regional 27 | Charleston def. Teutopolis, 48-45 |
| Regional 28 | Marshall JHS def. Lawrenceville Parkview, 54-33 |
| Sectional 15 @ Pana JHS, Pana |
| Pana JHS (17-3) vs. Greenville (18-2) |
| Regional 29 | Pana JHS def. Sullivan, 48-44 |
| Regional 30 | Greenville def. Effingham JHS, 42-31 |
| Sectional 16 @ Edward H. Wirth MS, Cahokia |
| Jerseyville Illini (19-4) vs. Cahokia Wirth (20-0) |
| Regional 31 | Jerseyville Illini def. Staunton, 36-32 |
| Regional 32 | Cahokia Wirth def. East St. Louis Lincoln, 47-40 |
