| Sectional 1 @ Bolingbrook Humphrey |
| Arlington Heights South (18-2) vs. Homer Glen Homer (18-2) |
| Regional 1 | Arlington Heights South def. Rockford West, 61-46 |
| Regional 2 | Homer Glen Homer def. Bellwood Roosevelt, 49-44 |
| Sectional 2 @ Harvey Brooks |
| Phoenix Coolidge (18-8) vs. Harvey Brooks |
| Regional 3 | Phoenix Coolidge def. Calumet City Dirksen, 38-34 |
| Regional 4 | Harvey Brooks def. Markham Prairie-Hills, 64-38 |
| Sectional 3 @ Beecher |
| Ford Heights Cottage Grove (13-2) vs. Frankfort Summit Hill (18-3) |
| Regional 5 | Ford Heights Cottage Grove def. Chicago Heights Washington, 47-40 |
| Regional 6 | Frankfort Summit Hill def. Mokena, 44-39 |
| Sectional 4 @ Channahon |
| Joliet Gompers vs. Shorewood Troy (5-17) |
| Regional 7 | Joliet Gompers def. Joliet Washington, 49-44 |
| Regional 8 | Shorewood Troy def. Minooka, 32-31 |
| Sectional 5 @ Manteno |
| Bourbonnais UGC vs. Onarga Iroquois West (13-7) |
| Regional 9 | Bourbonnais UGC def. Bradley Central |
| Regional 10 | Onarga Iroquois West def. Forrest Prairie Central, 33-28 |
| Sectional 6 @ Streator Northlawn |
| Morris Shabbona vs. Pontiac JHS (14-6) |
| Regional 12 | Pontiac JHS def. Streator Northlawn, 46-41 |
| Sectional 7 @ Georgetown Mary Miller |
| Danville North Ridge (15-4) vs. Champaign Franklin (18-2) |
| Regional 13 | Danville North Ridge def. Bismarck-Henning, 43-30 |
| Regional 14 | Champaign Franklin def. Champaign Edison, 36-32 |
| Sectional 8 @ Monticello |
| Normal Kingsley (18-4) vs. Bloomington JHS (15-6) |
| Regional 15 | Normal Kingsley def. Monticello, 41-35 |
| Regional 16 | Bloomington JHS def. Maroa-Forsyth, 52-35 |
| Sectional 9 @ Washington Central |
| Washington MS (19-1) vs. Morton JHS |
| Regional 17 | Washington MS def. Metamora GS, 42-25 |
| Regional 18 | Morton JHS def. Washington Beverly Manor, 54-21 |
| Sectional 10 @ Glasford Illini Bluffs |
| Peoria Christian (10-13) vs. Pekin Edison |
| Regional 19 | Peoria Christian def. Chillicothe, 52-47 |
| Regional 20 | Pekin Edison def. Canton Ingersoll, 48-35 |
| Sectional 11 @ Warrensburg-Latham |
| Decatur Mound (18-2) vs. Rochester |
| Regional 21 | Decatur Mound def. Mt. Zion, 55-39 |
| Regional 22 | Rochester def. Warrensburg-Latham, 31-15 |
| Sectional 12 @ Springfield Grant |
| Springfield Lincoln (15-7) vs. Jacksonville Turner (11-10) |
| Regional 23 | Springfield Lincoln def. Petersburg PORTA JHS, 46-32 |
| Regional 24 | Jacksonville Turner def. Springfield Franklin, 41-34 |
| Sectional 13 @ Colchester West Prairie |
| Macomb (17-6) vs. Pittsfield Pikeland |
| Regional 25 | Macomb def. Colchester West Prairie, 45-35 |
| Regional 26 | Pittsfield Pikeland def. Quincy, 43-36 |
| Sectional 14 @ Mattoon |
| Mattoon (12-9) vs. Marshall JHS (18-4) |
| Regional 27 | Mattoon def. Paris Crestwood, 21-16 |
| Regional 28 | Marshall JHS def. Newton Jasper County, 38-35 |
| Sectional 15 @ Effingham JHS |
| Effingham JHS vs. Taylorville JHS (17-4) |
| Regional 29 | Effingham JHS def. Teutopolis, 35-17 |
| Regional 30 | Taylorville JHS def. Hillsboro, 52-44 |
| Sectional 16 @ East St. Louis Lincoln |
| Jerseyville Illini (18-4) vs. East St. Louis Lincoln (19-2) |
| Regional 31 | Jerseyville Illini def. Carlinville, 48-26 |
| Regional 32 | East St. Louis Lincoln def. East St. Louis Clark, 64-51 |
