| Sectional 1 @ Joliet Laraway |
| Chicago St. Malachy (17-4) vs. Hopkins Park Lorenzo Smith (11-2) |
| Regional 1 | Chicago St. Malachy def. Joliet Laraway, 52-33 |
| Regional 2 | Hopkins Park Lorenzo Smith def. Donovan, 43-35 |
| Sectional 2 @ Cornell GS, Cornell |
| Mazon-Verona-Kinsman (16-6) vs. Pontiac St. Mary's (17-4) |
| Regional 3 | Mazon-Verona-Kinsman def. Mendota Holy Cross, 40-31 |
| Regional 4 | Pontiac St. Mary's def. Gardner, 49-23 |
| Sectional 3 @ Roanoke-Benson JHS, Benson |
| Wenona Fieldcrest East (19-3) vs. Metamora St. Mary's (11-10) |
| Regional 5 | Wenona Fieldcrest East def. Roanoke-Benson, 46-37 |
| Regional 6 | Metamora St. Mary's def. Washington St. Patrick, 34-22 |
| Sectional 4 @ Brimfield JHS, Brimfield |
| Peoria Christian (20-1) vs. Peoria Pleasant Valley (16-4) |
| Regional 7 | Peoria Christian def. Bartonville Monroe, 66-34 |
| Regional 8 | Peoria Pleasant Valley def. Elmwood, 51-29 |
| Sectional 5 @ Union ES, Biggsville |
| Monmouth United (10-8) vs. Lewistown Central (19-2) |
| Regional 9 | Monmouth United def. Biggsville Union, 37-30 |
| Regional 10 | Lewistown Central def. Avon, 49-15 |
| Sectional 6 @ Tri-Point JHS, Piper City |
| Milford (18-2) vs. Fisher (8-12) |
| Regional 11 | Milford def. Cissna Park, 42-37 (4 OT) |
| Regional 12 | Fisher def. Piper City Tri-Point, 29-25 |
| Sectional 7 @ Normal Epiphany |
| Bloomington Holy Trinity (20-1) vs. Normal Metcalf (19-3) |
| Regional 13 | Bloomington Holy Trinity def. Lexington, 53-26 |
| Regional 14 | Normal Metcalf def. Delavan, 51-37 |
| Sectional 8 @ Chrisman Scottland JHS, Chrisman |
| Philo St. Thomas (19-2) vs. Paris Crestwood (18-2) |
| Regional 15 | Philo St. Thomas def. Ogden, 38-33 |
| Regional 16 | Paris Crestwood def. Chrisman Scottland, 62-21 |
| Sectional 9 @ Lovington |
| Champaign Holy Cross (15-9) vs. Lovington (18-2) |
| Regional 17 | Champaign Holy Cross def. Champaign St. Matthew, 51-23 |
| Regional 18 | Lovington def. Cerro Gordo, 49-39 |
| Sectional 10 @ Divernon JHS, Divernon |
| Decatur St. Patrick (16-8) vs. Raymond Lincolnwood (20-2) |
| Regional 19 | Decatur St. Patrick def. Edinburg, 59-40 |
| Regional 20 | Raymond Lincolnwood def. Pawnee, 43-32 |
| Sectional 11 @ Mt. Pulaski GS, Mt. Pulaski |
| Lincoln Carroll Catholic (17-2) vs. Springfield St. Agnes (16-5) |
| Regional 21 | Lincoln Carroll Catholic def. Mt. Pulaski, 40-36 |
| Regional 22 | Springfield St. Agnes def. Springfield Calvary, 53-40 |
| Sectional 12 @ Virginia JHS, Virginia |
| Springfield Little Flower (19-2) vs. Concord Triopia (19-3) |
| Regional 23 | Springfield Little Flower def. Springfield Christ the King, 51-48 |
| Regional 24 | Concord Triopia def. Virginia, 41-37 |
| Sectional 13 @ Southeastern JHS, Bowen |
| Bowen Southeastern (19-1) vs. Griggsville-Perry (21-0) |
| Regional 25 | Bowen Southeastern def. Hamilton, 28-24 |
| Regional 26 | Griggsville-Perry def. Barry, 41-33 |
| Sectional 14 @ St. Anthony GS, Effingham |
| Newton St. Thomas (21-1) vs. Dieterich (20-2) |
| Regional 27 | Newton St. Thomas def. Oblong, 62-37 |
| Regional 28 | Dieterich def. Sigel St. Michael's, 33-18 |
| Sectional 15 @ TBD |
| Cowden-Herrick (19-3) vs. Nokomis JHS (15-7) |
| Regional 29 | Cowden-Herrick def. Windsor, 47-27 |
| Regional 30 | Nokomis JHS def. Mulberry Grove JHS, 46-22 |
| Sectional 16 @ St. John the Evangelist, Carrollton |
| Carrollton St. John (20-1) vs. Lovejoy (12-5) |
| Regional 31 | Carrollton St. John def. Hardin Calhoun, 57-21 |
| Regional 32 | Lovejoy def. Madison, 51-34 |
