| Sectional 1 @ Chicago St. Malachy |
| Chicago St. Malachy (12-10) vs. Donovan (19-1) |
| Regional 1 | Chicago St. Malachy def. Robbins Moody, 53-39 |
| Regional 2 | Donovan def. Hopkins Park Lorenzo Smith, 45-32 |
| Sectional 2 @ Wenona Fieldcrest East |
| Odell (18-3) vs. Wenona Fieldcrest East (20-2) |
| Regional 3 | Odell def. Elwood GS, 47-41 |
| Regional 4 | Wenona Fieldcrest East def. Tonica, 36-26 |
| Sectional 3 @ Royal Prairieview |
| Potomac vs. Fisher |
| Regional 5 | Potomac def. Cissna Park, 50-36 |
| Regional 6 | Fisher def. Royal Prairieview |
| Sectional 4 @ Toluca Fieldcrest West |
| Lexington vs. Toluca Fieldcrest West (20-0) |
| Regional 7 | Lexington def. Pontiac St. Mary's, 42-38 |
| Regional 8 | Toluca Fieldcrest West def. Roanoke-Benson, 36-33 |
| Sectional 5 @ Washington St. Patrick |
| Peoria Norwood (18-2) vs. Spring Bay Riverview (10-11) |
| Regional 9 | Peoria Norwood def. Bartonville Oak Grove West, 49-44 |
| Regional 10 | Spring Bay Riverview def. Delavan, 36-33 (OT) |
| Sectional 6 @ Williamsfield |
| Elmwood (12-9) vs. Farmington Chapman (19-1) |
| Regional 11 | Elmwood def. Brimfield, 64-53 |
| Regional 12 | Farmington Chapman def. Hanna City Logan, 51-40 |
| Sectional 7 @ Biggsville Union |
| Monmouth ICS (22-0) vs. Nauvoo-Colusa (18-3) |
| Regional 13 | Monmouth ICS def. Monmouth Yorkwood, 54-40 |
| Regional 14 | Nauvoo-Colusa def. Warsaw, 42-30 |
| Sectional 8 @ Chrisman Scottland |
| Champaign Holy Cross (16-6) vs. Chrisman Scottland (10-10) |
| Regional 15 | Champaign Holy Cross def. Homer Heritage, 50-42 |
| Regional 16 | Chrisman Scottland def. Catlin, 39-33 |
| Sectional 9 @ Buffalo Tri-City |
| Cerro Gordo (10-10) vs. Springfield Blessed Sacrament (16-5) |
| Regional 17 | Cerro Gordo def. Decatur Our Lady of Lourdes, 38-37 (OT) |
| Regional 18 | Springfield Blessed Sacrament def. Springfield St. Aloysius, 43-36 |
| Sectional 10 @ Hartsburg Emden |
| Bloomington Holy Trinity (18-4) vs. Hartsburg-Emden (20-0) |
| Regional 19 | Bloomington Holy Trinity def. Heyworth, 48-36 |
| Regional 20 | Hartsburg-Emden def. Mt. Pulaski, 41-30 |
| Sectional 11 @ Chandlerville A-C Central |
| Springfield Calvary (19-2) vs. Chandlerville A-C Central (17-5) |
| Regional 21 | Springfield Calvary def. Springfield Christ the King, 67-48 |
| Regional 22 | Chandlerville A-C Central def. Jacksonville Our Saviour, 23-21 |
| Sectional 12 @ Mt. Sterling Brown Co. |
| Liberty (12-10) vs. Griggsville-Perry (20-1) |
| Regional 23 | Liberty def. Bowen Southeastern, 40-30 |
| Regional 24 | Griggsville-Perry def. Kinderhook West Pike, 60-39 |
| Sectional 13 @ Effingham Sacred Heart |
| Newton St. Thomas vs. Effingham St. Anthony (21-1) |
| Regional 26 | Effingham St. Anthony def. St. Elmo, 33-21 |
| Sectional 14 @ Nokomis |
| Lovington (14-7) vs. Nokomis JHS (18-3) |
| Regional 27 | Lovington def. Arthur, 40-26 |
| Regional 28 | Nokomis JHS def. Stewardson-Strasburg, 44-38 |
| Sectional 15 @ Raymond Lincolnwood |
| Girard (20-1) vs. Greenfield |
| Regional 29 | Girard def. Pawnee, 54-40 |
| Regional 30 | Greenfield def. Carrollton St. John, 28-26 |
| Sectional 16 @ Mulberry Grove |
| Pocahontas (13-3) vs. Madison |
| Regional 31 | Pocahontas def. Mt. Olive, 53-41 |
| Regional 32 | Madison def. Lovejoy, 58-50 |
