| Sectional 1 @ South MS, Arlington Heights |
| Bellwood Roosevelt (10-1) vs. Woodridge Jefferson (14-3) |
| Regional 1 | Bellwood Roosevelt def. Arlington Heights South, 46-43 |
| Regional 2 | Woodridge Jefferson def. Bolingbrook Humphrey, 37-32 |
| Sectional 2 @ TBD |
| Calumet City Dirksen (10-4) vs. Harvey Brooks (16-1) |
| Regional 3 | Calumet City Dirksen def. Calumet City Schrum, 46-35 |
| Regional 4 | Harvey Brooks def. Dixmoor Rosa Parks, 65-58 |
| Sectional 3 @ TBD |
| Chicago Heights Washington (15-3) vs. Kankakee JHS (19-0) |
| Regional 5 | Chicago Heights Washington def. Ford Heights Cottage Grove, 48-37 |
| Regional 6 | Kankakee JHS def. Bourbonnais UGC, 43-25 |
| Sectional 4 @ Homer JHS, Homer Glen |
| Mokena (12-9) vs. Shorewood Troy (9-12) |
| Regional 7 | Mokena def. New Lenox Martino, 33-30 |
| Regional 8 | Shorewood Troy def. Romeoville Martinez, 47-23 |
| Sectional 5 @ Channahon JHS, Channahon |
| Wilmington Stevens (20-2) vs. Dwight (18-3) |
| Regional 9 | Wilmington Stevens def. Channahon, 36-30 |
| Regional 10 | Dwight def. Streator Northlawn, 44-37 |
| Sectional 6 @ Prairie Central JHS, Forrest |
| Paxton-Buckley-Loda (13-6) vs. Normal Kingsley (19-1) |
| Regional 11 | Paxton-Buckley-Loda def. Gibson City GCMS, 38-29 |
| Regional 12 | Normal Kingsley def. Normal Chiddix, 31-29 |
| Sectional 7 @ Morton JHS, Morton |
| Eureka (21-0) vs. Stanford Olympia (13-8) |
| Regional 13 | Eureka def. Washington Central, 29-18 |
| Regional 14 | Stanford Olympia def. East Peoria Central, 31-20 |
| Sectional 8 @ Georgetowne MS, Marquette Heights |
| Dunlap MS (18-4) vs. Pekin Edison (18-1) |
| Regional 15 | Dunlap MS def. Marquette Heights Georgetowne, 42-38 |
| Regional 16 | Pekin Edison def. Canton Ingersoll, 43-35 |
| Sectional 9 @ West Prairie MS, Colchester |
| Sherrard JHS (21-1) vs. Quincy (16-4) |
| Regional 17 | Sherrard JHS def. Abingdon, 41-19 |
| Regional 18 | Quincy def. Pittsfield Pikeland, 44-28 |
| Sectional 10 @ TBD |
| Westville JHS (16-7) vs. Champaign Edison (19-1) |
| Regional 19 | Westville JHS def. Danville North Ridge, 45-41 |
| Regional 20 | Champaign Edison def. St. Joseph, 47-23 |
| Sectional 11 @ Clinton JHS, Clinton |
| Mahomet-Seymour (15-6) vs. Heyworth (22-0) |
| Regional 21 | Mahomet-Seymour def. Tolono Unity, 57-50 |
| Regional 22 | Heyworth def. Maroa-Forsyth, 44-33 |
| Sectional 12 @ Rochester JHS, Rochester |
| Decatur Stephen Decatur (16-1) vs. Springfield Jefferson |
| Regional 23 | Decatur Stephen Decatur def. Decatur Jefferson, 49-28 |
| Regional 24 | Springfield Jefferson def. Williamsville, 41-32 |
| Sectional 13 @ Havana JHS, Havana |
| Springfield Franklin (17-3) vs. Jacksonville Turner (18-1) |
| Regional 25 | Springfield Franklin def. Havana, 60-32 |
| Regional 26 | Jacksonville Turner def. Auburn, 49-39 |
| Sectional 14 @ Jasper County JHS, Newton |
| Charleston (12-9) vs. Marshall JHS (16-5) |
| Regional 27 | Charleston def. Teutopolis, 35-22 |
| Regional 28 | Marshall JHS def. Sumner Red Hill, 51-35 |
| Sectional 15 @ Vandalia JHS, Vandalia |
| Blue Mound Meridian (19-3) vs. Effingham JHS (16-1) |
| Regional 29 | Blue Mound Meridian def. Shelbyville Moulton, 50-32 |
| Regional 30 | Effingham JHS def. Hillsboro, 45-16 |
| Sectional 16 @ Carlinville MS, Carlinville |
| Piasa Southwestern (20-5) vs. Cahokia Wirth (11-0) |
| Regional 31 | Piasa Southwestern def. Jerseyville Illini, 29-22 |
| Regional 32 | Cahokia Wirth def. East St. Louis Younge, 38-35 |
