| Sectional 1 @ Arlington Heights South |
| Arlington Heights South (14-2) vs. Homer Glen Homer (18-2) |
| Regional 1 | Arlington Heights South def. Bellwood Roosevelt, 31-26 |
| Regional 2 | Homer Glen Homer def. Bolingbrook Humphrey, 37-24 |
| Sectional 2 @ Markham Prairie Hills |
| Calumet City Dirksen (12-2) vs. Markham Prairie-Hills (16-0) |
| Regional 3 | Calumet City Dirksen def. Calumet City Schrum, 52-27 |
| Regional 4 | Markham Prairie-Hills def. Harvey Brooks, 59-33 |
| Sectional 3 @ Ford Heights Cottage Grove |
| Ford Heights Cottage Grove (14-3) vs. Mokena (18-2) |
| Regional 5 | Ford Heights Cottage Grove def. Chicago Heights Washington, 43-36 |
| Regional 6 | Mokena def. New Lenox Liberty, 32-20 |
| Sectional 4 @ Joliet Washington |
| Joliet Gompers vs. Channahon (17-0) |
| Regional 7 | Joliet Gompers def. Joliet Washington, 50-48 (3 OT) |
| Regional 8 | Channahon def. Shorewood Troy, 47-24 |
| Sectional 5 @ Onarga Iroquois West |
| Bourbonnais UGC vs. Forrest Prairie Central (14-10) |
| Regional 9 | Bourbonnais UGC def. Manteno, 38-26 |
| Regional 10 | Forrest Prairie Central def. Onarga Iroquois West, 36-28 |
| Sectional 6 @ Streator Northlawn |
| Dwight (13-7) vs. Streator Northlawn (14-7) |
| Regional 11 | Dwight def. Morris Shabbona, 25-19 |
| Regional 12 | Streator Northlawn def. Peru Washington, 34-28 |
| Sectional 7 @ Tolono Unity |
| Danville North Ridge (17-4) vs. Champaign Franklin |
| Regional 13 | Danville North Ridge def. St. Joseph, 42-37 |
| Regional 14 | Champaign Franklin def. Champaign Edison, 37-30 |
| Sectional 8 @ Stanford Olympia |
| Normal Parkside (14-8) vs. Bloomington JHS |
| Regional 15 | Normal Parkside def. Normal Kingsley, 40-37 |
| Regional 16 | Bloomington JHS def. Stanford Olympia |
| Sectional 9 @ Tremont |
| Washington Central vs. Morton JHS (17-4) |
| Regional 17 | Washington Central def. Eureka, 42-29 |
| Regional 18 | Morton JHS def. East Peoria Central, 53-44 |
| Sectional 10 @ Dunlap |
| Peoria Christian (20-2) vs. Pekin Broadmoor |
| Regional 19 | Peoria Christian def. Chillicothe, 57-26 |
| Regional 20 | Pekin Broadmoor def. Canton Ingersoll, 52-24 |
| Sectional 11 @ Rochester |
| Mt. Zion (20-1) vs. Blue Mound Meridian (21-1) |
| Regional 21 | Mt. Zion def. Decatur Stephen Decatur, 55-44 |
| Regional 22 | Blue Mound Meridian def. Rochester, 35-25 |
| Sectional 12 @ Chatham Glenwood |
| Springfield Lincoln (16-6) vs. Springfield Franklin (19-1) |
| Regional 23 | Springfield Lincoln def. Pleasant Plains, 33-27 |
| Regional 24 | Springfield Franklin def. Springfield Jefferson, 44-28 |
| Sectional 13 @ Colchester West Prairie |
| Macomb (17-7) vs. Quincy (13-3) |
| Regional 25 | Macomb def. Aledo, 34-24 |
| Regional 26 | Quincy def. Camp Point Central, 49-37 |
| Sectional 14 @ Marshall |
| Paris Crestwood (21-0) vs. Lawrenceville Parkview (14-5) |
| Regional 27 | Paris Crestwood def. Charleston, 54-37 |
| Regional 28 | Lawrenceville Parkview def. Marshall JHS, 43-28 |
| Sectional 15 @ Assumption Central A&M |
| Sullivan (19-2) vs. Taylorville JHS (15-6) |
| Regional 29 | Sullivan def. Altamont, 58-43 |
| Regional 30 | Taylorville JHS def. Pana JHS, 36-31 |
| Sectional 16 @ Carlinville |
| Jerseyville Illini (20-2) vs. Cahokia Wirth (12-3) |
| Regional 31 | Jerseyville Illini def. Piasa Southwestern, 46-30 |
| Regional 32 | Cahokia Wirth def. East St. Louis Young, 46-38 |
