| Sectional 1 @ Homer Glen Homer |
| Bellwood Roosevelt (10-3) vs. Bolingbrook Brooks |
| Regional 1 | Bellwood Roosevelt def. Rockford West, 38-34 |
| Regional 2 | Bolingbrook Brooks def. Lockport Oak Prairie, 25-21 |
| Sectional 2 @ Mokena |
| Markham Prairie-Hills (21-1) vs. Mokena (18-4) |
| Regional 3 | Markham Prairie-Hills def. Country Club Hills Southwood, 34-28 |
| Regional 4 | Mokena def. Frankfort Summit Hill, 33-24 |
| Sectional 3 @ Lincoln School, Dolton |
| Calumet City Dirksen (15-1) vs. University Park Crete Monee (4-1) |
| Regional 5 | Calumet City Dirksen def. Dolton Lincoln, 47-36 |
| Regional 6 | University Park Crete Monee def. Calumet Park, 50-27 |
| Sectional 4 @ Manteno |
| Manteno (18-3) vs. Herscher Limestone (17-3) |
| Regional 7 | Manteno def. Coal City, 25-23 |
| Regional 8 | Herscher Limestone def. Bradley Central, 34-22 |
| Sectional 5 @ Channahon |
| Shorewood Troy vs. Ottawa Shepherd (20-0) |
| Regional 9 | Shorewood Troy def. Channahon, 39-29 |
| Regional 10 | Ottawa Shepherd def. Minooka, 30-25 |
| Sectional 6 @ Prairie Central JHS, Forrest |
| Pontiac JHS (20-1) vs. Rantoul Eater (14-7) |
| Regional 11 | Pontiac JHS def. Clifton Nash, 34-18 |
| Regional 12 | Rantoul Eater def. Onarga Iroquois West, 39-23 |
| Sectional 7 @ Parkside JHS, Normal |
| Stanford Olympia (19-1) vs. Maroa-Forsyth |
| Regional 13 | Stanford Olympia def. Bloomington JHS, 30-21 |
| Regional 14 | Maroa-Forsyth def. Downs Tri-Valley, 29-22 |
| Sectional 8 @ Dunlap |
| Washington MS (18-2) vs. Dunlap MS (17-3) |
| Regional 15 | Washington MS def. Metamora Germantown Hills, 46-17 |
| Regional 16 | Dunlap MS def. East Peoria Central, 37-23 |
| Sectional 9 @ Green Valley Midwest Central |
| Green Valley Midwest Central (14-6) vs. Canton Ingersoll (21-1) |
| Regional 17 | Green Valley Midwest Central def. Pekin Edison, 43-33 |
| Regional 18 | Canton Ingersoll def. Havana, 36-28 |
| Sectional 10 @ Mahomet-Seymour |
| St. Joseph (16-4) vs. Mahomet-Seymour (14-7) |
| Regional 19 | St. Joseph def. Danville Oakwood, 38-18 |
| Regional 20 | Mahomet-Seymour def. Tolono Unity, 24-18 |
| Sectional 11 @ Riverton |
| Sullivan (19-2) vs. Taylorville JHS (21-1) |
| Regional 21 | Sullivan def. Decatur Stephen Decatur, 43-37 |
| Regional 22 | Taylorville JHS def. Rochester, 23-20 |
| Sectional 12 @ Glenwood MS, Chatham |
| Springfield Franklin vs. Chatham Glenwood (20-0) |
| Regional 23 | Springfield Franklin def. Williamsville, 35-32 |
| Regional 24 | Chatham Glenwood def. Auburn, 63-1 |
| Sectional 13 @ Pittsfield Pikeland |
| Macomb vs. Quincy (17-3) |
| Regional 25 | Macomb def. Bushnell-Prairie City, 35-27 |
| Regional 26 | Quincy def. Liberty, 39-30 |
| Sectional 14 @ Charleston |
| Charleston (17-4) vs. Newton Jasper County |
| Regional 27 | Charleston def. Paris Mayo, 46-21 |
| Regional 28 | Newton Jasper County def. Sumner Red Hill, 28-26 |
| Sectional 15 @ Vandalia |
| Mattoon (16-5) vs. Litchfield (20-1) |
| Regional 29 | Mattoon def. Teutopolis, 22-12 |
| Regional 30 | Litchfield def. Hillsboro, 36-29 |
| Sectional 16 @ Carlinville |
| Piasa Southwestern (15-4) vs. Edwardsville Lincoln (17-3) |
| Regional 31 | Piasa Southwestern def. Staunton, 34-25 |
| Regional 32 | Edwardsville Lincoln def. East St. Louis Younge, 21-17 |
