| Sectional 1 @ Morris Saratoga |
| Chicago St. Malachy (15-2) vs. Seneca (12-9) |
| Regional 1 | Chicago St. Malachy def. Beecher, 45-37 |
| Regional 2 | Seneca def. Crest Hill Richland, 47-41 |
| Sectional 2 @ Grand Ridge |
| Tonica (14-9) vs. Streator St. Stephen (17-3) |
| Regional 3 | Tonica def. Oglesby Washington, 33-28 |
| Regional 4 | Streator St. Stephen def. Streator Woodland, 30-16 |
| Sectional 3 @ Tri-Point JHS, Piper City |
| Milford (15-3) vs. Gifford (12-9) |
| Regional 5 | Milford def. Donovan, 36-18 |
| Regional 6 | Gifford def. Cissna Park, 23-14 |
| Sectional 4 @ Normal Epiphany |
| Odell (15-5) vs. Normal Epiphany (21-1) |
| Regional 7 | Odell def. Roanoke-Benson, 52-46 |
| Regional 8 | Normal Epiphany def. Bloomington Holy Trinity, 33-31 (3 OT) |
| Sectional 5 @ Washington St. Patrick |
| Sparland Midland (15-4) vs. Bartonville Monroe (15-6) |
| Regional 9 | Sparland Midland def. Toluca Fieldcrest West, 32-21 |
| Regional 10 | Bartonville Monroe def. Bartonville Oak Grove West, 39-37 |
| Sectional 6 @ Cuba Middle School |
| Peoria Norwood (14-6) vs. Cuba (11-8) |
| Regional 11 | Peoria Norwood def. Peoria Limestone Walters, 37-32 |
| Regional 12 | Cuba def. Elmwood |
| Sectional 7 @ Colchester West Prairie |
| Media Southern (20-0) vs. Hamilton |
| Regional 13 | Media Southern def. Abingdon, 43-32 |
| Regional 14 | Hamilton def. Carthage, 22-11 |
| Sectional 8 @ Catlin |
| Catlin (18-1) vs. Royal Prairieview (13-7) |
| Regional 15 | Catlin def. Bismarck-Henning, 33-19 |
| Regional 16 | Royal Prairieview def. Homer Heritage, 24-18 |
| Sectional 9 @ G.C.M.S. MS, Gibson City |
| Rantoul St. Malachy (20-1) vs. Champaign St. Matthew (19-3) |
| Regional 17 | Rantoul St. Malachy def. Gibson City GCMS, 24-22 |
| Regional 18 | Champaign St. Matthew def. Mansfield Blue Ridge JHS, 32-16 |
| Sectional 10 @ Oakland Lake Crest |
| Paris Crestwood (21-0) vs. Tuscola East Prairie (17-5) |
| Regional 19 | Paris Crestwood def. Oakland Lake Crest, 44-11 |
| Regional 20 | Tuscola East Prairie def. Sigel St. Michael's, 33-20 |
| Sectional 11 @ Central A & M MS, Assumption |
| Decatur Johns Hill vs. Assumption Central A & M (17-4) |
| Regional 21 | Decatur Johns Hill def. Arthur, 32-27 |
| Regional 22 | Assumption Central A & M def. Pana Sacred Heart, 45-23 |
| Sectional 12 @ Pawnee |
| Springfield Blessed Sacrament (21-2) vs. Pawnee (13-5) |
| Regional 23 | Springfield Blessed Sacrament def. Jacksonville ISD, 30-17 |
| Regional 24 | Pawnee def. Kincaid South Fork, 48-19 |
| Sectional 13 @ Virginia |
| Lincoln Chester-East Lincoln (16-3) vs. Springfield St. Agnes (18-4) |
| Regional 25 | Lincoln Chester-East Lincoln def. Lincoln Carroll Catholic, 26-22 |
| Regional 26 | Springfield St. Agnes def. Springfield Christ the King, 31-27 |
| Sectional 14 @ Brown County MS, Mt. Sterling |
| Griggsville-Perry (16-6) vs. Winchester (15-6) |
| Regional 27 | Griggsville-Perry def. Mt. Sterling Brown County, 28-25 |
| Regional 28 | Winchester def. Bluffs, 21-16 |
| Sectional 15 @ St. Anthony GS, Effingham |
| Noble West Richland (11-3) vs. Beecher City (17-3) |
| Regional 29 | Noble West Richland def. Palestine, 37-32 |
| Regional 30 | Beecher City def. Effingham St. Anthony, 44-38 |
| Sectional 16 @ Greenfield High School, Greenfield |
| Greenfield (18-0) vs. Bunker Hill Meissner (7-13) |
| Regional 31 | Greenfield def. Jerseyville St. Francis HG, 32-19 |
| Regional 32 | Bunker Hill Meissner def. East St. Louis Jackson, 38-30 (OT) |
