| Sectional 1 @ Bolingbrook Jane Addams |
| Bellwood Roosevelt (10-2) vs. Bolingbrook Jane Addams (15-1) |
| Regional 1 | Bellwood Roosevelt def. Rockford West, 39-38 |
| Regional 2 | Bolingbrook Jane Addams def. Homer Glen Homer, 21-18 |
| Sectional 2 @ Mokena |
| Harvey Brooks vs. New Lenox Liberty (17-2) |
| Regional 3 | Harvey Brooks def. Markham Prairie-Hills, 30-27 |
| Regional 4 | New Lenox Liberty def. Manhattan, 25-13 |
| Sectional 3 @ Calumet Park Recreation Center, Calumet Park |
| Phoenix Coolidge (11-10) vs. Calumet Park (10-2) |
| Regional 5 | Phoenix Coolidge def. Calumet City Lincoln, 45-33 |
| Regional 6 | Calumet Park def. Ford Heights Cottage Grove, 17-7 |
| Sectional 4 @ Peotone |
| Coal City (20-1) vs. Herscher Limestone (17-2) |
| Regional 7 | Coal City def. Peotone, 38-18 |
| Regional 8 | Herscher Limestone def. Bradley Central, 25-12 |
| Sectional 5 @ Channahon |
| Joliet Washington (22-0) vs. Ottawa Shepherd (19-1) |
| Regional 9 | Joliet Washington def. Joliet Hufford, 28-13 |
| Regional 10 | Ottawa Shepherd def. Minooka, 25-16 |
| Sectional 6 @ Onarga Iroquois West |
| Forrest Prairie Central (21-1) vs. Rantoul Eater (15-6) |
| Regional 11 | Forrest Prairie Central def. Pontiac JHS, 30-15 |
| Regional 12 | Rantoul Eater def. Watseka Glenn Raymond, 25-22 |
| Sectional 7 @ Chiddix JHS, Normal |
| Normal Kingsley (18-0) vs. Downs Tri-Valley |
| Regional 13 | Normal Kingsley def. Bloomington JHS, 36-14 |
| Regional 14 | Downs Tri-Valley def. Maroa-Forsyth, 23-20 |
| Sectional 8 @ Central GS, Washington |
| Metamora Germantown Hills (17-1) vs. East Peoria Central (16-3) |
| Regional 15 | Metamora Germantown Hills def. Eureka, 31-19 |
| Regional 16 | East Peoria Central def. Dunlap MS, 30-21 |
| Sectional 9 @ Farmington Central |
| Pekin Edison (18-3) vs. Canton Ingersoll (21-0) |
| Regional 17 | Pekin Edison def. Morton JHS, 31-26 |
| Regional 18 | Canton Ingersoll def. Havana, 42-19 |
| Sectional 10 @ Oakwood JHS, Danville |
| Danville Oakwood vs. Champaign Franklin (10-8) |
| Regional 19 | Danville Oakwood def. St. Joseph, 35-22 |
| Regional 20 | Champaign Franklin def. Champaign Edison, 35-25 |
| Sectional 11 @ Rochester |
| Blue Mound Meridian (15-7) vs. Rochester (15-6) |
| Regional 21 | Blue Mound Meridian def. Decatur Jefferson, 32-28 |
| Regional 22 | Rochester def. Taylorville JHS, 26-24 (OT) |
| Sectional 12 @ Williamsville |
| Petersburg PORTA JHS vs. Chatham Glenwood (17-3) |
| Regional 23 | Petersburg PORTA JHS def. Springfield Franklin, 30-24 |
| Regional 24 | Chatham Glenwood def. Pleasant Plains, 37-21 |
| Sectional 13 @ Pittsfield Pikeland |
| Bushnell-Prairie City (17-4) vs. Quincy (15-1) |
| Regional 25 | Bushnell-Prairie City def. Beardstown JHS, 31-13 |
| Regional 26 | Quincy def. Pittsfield Pikeland, 35-25 |
| Sectional 14 @ Newton Jasper County |
| Toledo Cumberland (21-0) vs. Sumner Red Hill (15-4) |
| Regional 27 | Toledo Cumberland def. Charleston, 28-22 |
| Regional 28 | Sumner Red Hill def. Lawrenceville Parkview, 20-19 |
| Sectional 15 @ Vandalia |
| Teutopolis (20-0) vs. Hillsboro (20-1) |
| Regional 29 | Teutopolis def. Mattoon, 21-11 |
| Regional 30 | Hillsboro def. Greenville, 47-23 |
| Sectional 16 @ Edward H. Wirth MS, Cahokia |
| Carlinville (20-2) vs. Cahokia Wirth (16-7) |
| Regional 31 | Carlinville def. Piasa Southwestern, 31-25 |
| Regional 32 | Cahokia Wirth def. Edwardsville Liberty, 25-21 |
