| Sectional 1 @ Richland GS, Crest Hill |
| Beecher vs. Crest Hill Richland (12-5) |
| Regional 1 | Beecher def. Riverdale Patton, 32-24 |
| Regional 2 | Crest Hill Richland def. Morris Saratoga, 28-18 |
| Sectional 2 @ Fieldcrest East MS, Wenona |
| Tonica (17-4) vs. Streator St. Stephen (19-1) |
| Regional 3 | Tonica def. Grand Ridge, 36-23 |
| Regional 4 | Streator St. Stephen def. Streator St. Anthony, 45-23 |
| Sectional 3 @ Tri-Point JHS, Piper City |
| Donovan (8-7) vs. Gifford (14-5) |
| Regional 5 | Donovan def. Milford, 38-36 |
| Regional 6 | Gifford def. Piper City Tri-Point, 29-11 |
| Sectional 4 @ Roanoke-Benson |
| Pontiac St. Mary's (20-1) vs. Normal Epiphany (21-1) |
| Regional 7 | Pontiac St. Mary's def. Lexington, 33-19 |
| Regional 8 | Normal Epiphany def. Bloomington Holy Trinity, 29-18 |
| Sectional 5 @ Washington St. Patrick |
| Peoria Pleasant Valley (16-3) vs. Mackinaw Dee-Mack |
| Regional 9 | Peoria Pleasant Valley def. Sparland Midland, 35-30 |
| Regional 10 | Mackinaw Dee-Mack def. Spring Bay Riverview |
| Sectional 6 @ Brimfield |
| Brimfield (19-1) vs. Lewistown Central (14-5) |
| Regional 11 | Brimfield def. Princeville, 56-6 |
| Regional 12 | Lewistown Central def. London Mills Valley, 45-33 |
| Sectional 7 @ Biggsville Union |
| Abingdon (13-9) vs. Colchester West Prairie (13-10) |
| Regional 13 | Abingdon def. Roseville, 23-18 |
| Regional 14 | Colchester West Prairie def. Hamilton, 41-35 |
| Sectional 8 @ Jamaica JHS, Sidell |
| Potomac (11-2) vs. Sidell Jamaica (14-3) |
| Regional 15 | Potomac def. Bismarck-Henning, 27-19 |
| Regional 16 | Sidell Jamaica def. Homer Heritage, 26-7 |
| Sectional 9 @ Fisher |
| LeRoy (10-9) vs. Champaign St. Matthew (14-8) |
| Regional 17 | LeRoy def. Gibson City GCMS, 16-15 (OT) |
| Regional 18 | Champaign St. Matthew def. Champaign Holy Cross, 28-27 |
| Sectional 10 @ Oakland Lake Crest |
| Paris Crestwood (14-4) vs. Tuscola East Prairie (14-8) |
| Regional 19 | Paris Crestwood def. Hume Shiloh, 26-8 |
| Regional 20 | Tuscola East Prairie def. Arcola, 22-7 |
| Sectional 11 @ Central A & M MS, Assumption |
| Cerro Gordo (15-7) vs. Assumption Central A & M (16-4) |
| Regional 21 | Cerro Gordo def. Decatur Johns Hill, 41-24 |
| Regional 22 | Assumption Central A & M def. Pana Sacred Heart, 37-19 |
| Sectional 12 @ Divernon |
| Springfield Blessed Sacrament (18-4) vs. Nokomis JHS (7-10) |
| Regional 23 | Springfield Blessed Sacrament def. Jacksonville Our Saviour, 28-23 |
| Regional 24 | Nokomis JHS def. Divernon, 37-20 |
| Sectional 13 @ A-C Central JHS, Chandlerville |
| Mt. Pulaski (14-2) vs. Springfield St. Agnes (15-5) |
| Regional 25 | Mt. Pulaski def. Lincoln Carroll Catholic, 29-10 |
| Regional 26 | Springfield St. Agnes def. Springfield Christ the King, 31-27 |
| Sectional 14 @ Brown County MS, Mt. Sterling |
| Mendon Unity (21-2) vs. Winchester (17-3) |
| Regional 27 | Mendon Unity def. Bowen Southeastern, 28-25 |
| Regional 28 | Winchester def. Concord Triopia, 25-22 |
| Sectional 15 @ St. Anthony GS, Effingham |
| Palestine (6-7) vs. Louisville North Clay (13-5) |
| Regional 29 | Palestine def. Noble West Richland, 37-17 |
| Regional 30 | Louisville North Clay def. Effingham St. Anthony, 28-21 |
| Sectional 16 @ Carrollton St. John |
| Carrollton St. John vs. Bunker Hill Meissner (14-6) |
| Regional 31 | Carrollton St. John def. Greenfield, 28-16 |
| Regional 32 | Bunker Hill Meissner def. Mt. Olive, 37-7 |
