| Sectional 1 @ Joliet Laraway |
| Chicago San Miguel Comer (10-2) vs. Joliet Laraway (21-3) |
| Regional 1 | Chicago San Miguel Comer def. Chicago Providence-St. Mel, 53-46 |
| Regional 2 | Joliet Laraway def. Grant Park, 62-26 |
| Sectional 2 @ Saunemin |
| Morris Saratoga (15-5) vs. Pontiac St. Mary's (19-2) |
| Regional 3 | Morris Saratoga def. Seneca, 36-27 |
| Regional 4 | Pontiac St. Mary's def. Saunemin, 39-26 |
| Sectional 3 @ Roanoke-Benson |
| Ottawa Wallace (16-7) vs. Toluca Fieldcrest West (20-0) |
| Regional 5 | Ottawa Wallace def. Mendota Holy Cross, 57-43 |
| Regional 6 | Toluca Fieldcrest West def. Wenona Fieldcrest East, 37-18 |
| Sectional 4 @ Cissna Park |
| Cissna Park (15-6) vs. Royal Prairieview (17-5) |
| Regional 7 | Cissna Park def. Crescent City, 35-20 |
| Regional 8 | Royal Prairieview def. Rantoul St. Malachy, 43-39 |
| Sectional 5 @ Chrisman Scottland |
| Chrisman Scottland (17-3) vs. Champaign Holy Cross (16-6) |
| Regional 9 | Chrisman Scottland def. Catlin, 53-24 |
| Regional 10 | Champaign Holy Cross def. Champaign St. Matthew, 40-35 (OT) |
| Sectional 6 @ Fisher |
| Fisher (15-5) vs. Lexington (14-7) |
| Regional 11 | Fisher def. LeRoy, 30-24 |
| Regional 12 | Lexington def. Bloomington Cornerstone, 34-33 |
| Sectional 7 @ Delavan |
| Delavan (12-8) vs. Lincoln West Lincoln-Broadwell (18-1) |
| Regional 13 | Delavan def. Metamora St. Mary's, 33-32 |
| Regional 14 | Lincoln West Lincoln-Broadwell def. Greenview, 64-39 |
| Sectional 8 @ Peoria Pleasant Valley |
| Peoria Pleasant Valley (12-7) vs. Lewistown Central (18-6) |
| Regional 15 | Peoria Pleasant Valley def. Peoria Christian, 49-33 |
| Regional 16 | Lewistown Central def. Glasford Illini Bluffs, 43-36 |
| Sectional 9 @ Elmwood |
| Woodhull AlWood (9-8) vs. Elmwood (20-1) |
| Regional 17 | Woodhull AlWood def. Abingdon, 35-32 |
| Regional 18 | Elmwood def. Brimfield, 57-36 |
| Sectional 10 @ Stewardson-Strasburg |
| Stewardson-Strasburg (15-6) vs. Arthur (16-3) |
| Regional 19 | Stewardson-Strasburg def. Neoga, 37-23 |
| Regional 20 | Arthur def. Cerro Gordo, 31-30 |
| Sectional 11 @ Raymond-Lincolnwood |
| Decatur St. Patrick (19-7) vs. Raymond Lincolnwood (20-1) |
| Regional 21 | Decatur St. Patrick def. Decatur Our Lady of Lourdes, 38-36 |
| Regional 22 | Raymond Lincolnwood def. Nokomis JHS, 35-30 |
| Sectional 12 @ Springfield Calvary |
| Springfield Christ the King (17-5) vs. Springfield St. Agnes (17-2) |
| Regional 23 | Springfield Christ the King def. Pawnee, 41-15 |
| Regional 24 | Springfield St. Agnes def. Springfield Calvary, 57-55 |
| Sectional 13 @ Waverly |
| Chandlerville A-C Central (15-6) vs. Pleasant Hill (14-7) |
| Regional 25 | Chandlerville A-C Central def. Palmyra Northwestern, 45-38 |
| Regional 26 | Pleasant Hill def. Concord Triopia, 50-42 |
| Sectional 14 @ Carthage |
| Bowen Southeastern (17-5) vs. Barry (19-2) |
| Regional 27 | Bowen Southeastern def. La Harpe, 37-33 |
| Regional 28 | Barry def. Payson Seymour, 43-39 |
| Sectional 15 @ Effingham St. Anthony |
| Effingham St. Anthony (14-4) vs. Brownstown (17-4) |
| Regional 29 | Effingham St. Anthony def. Dieterich, 39-29 |
| Regional 30 | Brownstown def. Effingham Sacred Heart, 44-26 |
| Sectional 16 @ Mt. Olive |
| Pocahontas (15-1) vs. Jerseyville St. Francis HG (16-4) |
| Regional 31 | Pocahontas def. Mt. Olive, 51-22 |
| Regional 32 | Jerseyville St. Francis HG def. Greenfield, 41-33 |
