| Sectional 1 @ Arlington Heights South |
| Bellwood Roosevelt (9-3) vs. Bolingbrook Jane Addams |
| Regional 1 | Bellwood Roosevelt def. Arlington Heights South, 40-32 |
| Regional 2 | Bolingbrook Jane Addams def. Lockport Oak Prairie, 48-31 |
| Sectional 2 @ Harvey Brooks |
| Harvey Brooks (14-0) vs. Calumet City Schrum (16-3) |
| Regional 3 | Harvey Brooks def. Phoenix Coolidge, 62-40 |
| Regional 4 | Calumet City Schrum def. Lansing Heritage, 56-29 |
| Sectional 3 @ Park Forest Forest Trail |
| Markham Prairie-Hills (14-6) vs. Park Forest Forest Trail (14-4) |
| Regional 5 | Markham Prairie-Hills def. Country Club Hills Southwood, 35-33 |
| Regional 6 | Park Forest Forest Trail def. Steger Columbia, 58-33 |
| Sectional 4 @ Mokena |
| Mokena (18-2) vs. Joliet Gompers (13-3) |
| Regional 7 | Mokena def. Homer Glen Homer, 38-29 |
| Regional 8 | Joliet Gompers def. New Lenox Liberty, 49-33 |
| Sectional 5 @ Rockford West |
| Shorewood Troy (16-2) vs. Ottawa Shepherd (18-3) |
| Regional 9 | Shorewood Troy def. Channahon, 36-27 |
| Regional 10 | Ottawa Shepherd def. Rockford West, 32-28 |
| Sectional 6 @ Onarga Iroquois West |
| Bourbonnais UGC (19-1) vs. Paxton-Buckley-Loda (18-2) |
| Regional 11 | Bourbonnais UGC def. Kankakee JHS, 30-25 |
| Regional 12 | Paxton-Buckley-Loda def. Watseka Glenn Raymond, 39-30 |
| Sectional 7 @ Normal Chiddix |
| Bloomington JHS (17-3) vs. Metamora GS (16-7) |
| Regional 13 | Bloomington JHS def. Normal Kingsley, 31-26 |
| Regional 14 | Metamora GS def. Eureka, 41-35 |
| Sectional 8 @ Morton |
| Chillicothe (17-3) vs. Morton JHS (19-2) |
| Regional 15 | Chillicothe def. Sparland Midland, 37-22 |
| Regional 16 | Morton JHS def. East Peoria Central, 28-24 |
| Sectional 9 @ Farmington Central |
| Pekin Edison (11-8) vs. Macomb (20-1) |
| Regional 17 | Pekin Edison def. Canton Ingersoll, 43-21 |
| Regional 18 | Macomb def. Monmouth-Roseville JHS, 52-29 |
| Sectional 10 @ Danville North Ridge |
| Danville North Ridge (22-0) vs. Rantoul Eater (12-2) |
| Regional 19 | Danville North Ridge def. Danville South View, 64-36 |
| Regional 20 | Rantoul Eater def. Champaign Jefferson, 48-32 |
| Sectional 11 @ Tolono Unity |
| Tolono Unity (17-3) vs. Lincoln JHS (17-4) |
| Regional 21 | Tolono Unity def. Monticello, 38-18 |
| Regional 22 | Lincoln JHS def. Warrensburg-Latham, 37-36 |
| Sectional 12 @ Pittsfield Pikeland |
| Pleasant Plains (19-3) vs. Quincy (21-1) |
| Regional 23 | Pleasant Plains def. Jacksonville Turner, 32-23 |
| Regional 24 | Quincy def. Camp Point Central, 52-25 |
| Sectional 13 @ Charleston |
| Charleston (15-5) vs. Sumner Red Hill (20-1) |
| Regional 25 | Charleston def. Paris Mayo, 54-30 |
| Regional 26 | Sumner Red Hill def. Teutopolis, 35-27 |
| Sectional 14 @ Rochester |
| Decatur Jefferson vs. Rochester (21-0) |
| Regional 27 | Decatur Jefferson def. Sullivan, 42-24 |
| Regional 28 | Rochester def. Decatur Stephen Decatur, 44-26 |
| Sectional 15 @ Carlinville |
| Springfield Grant (19-1) vs. Auburn (18-2) |
| Regional 29 | Springfield Grant def. Springfield Jefferson, 50-32 |
| Regional 30 | Auburn def. Jerseyville Illini, 37-25 |
| Sectional 16 @ East St. Louis Lincoln |
| Edwardsville Liberty (16-3) vs. East St. Louis Younge (18-3) |
| Regional 31 | Edwardsville Liberty def. Litchfield, 41-26 |
| Regional 32 | East St. Louis Younge def. Cahokia Wirth, 63-60 |
