| Sectional 1 @ Donovan |
| Riverdale Patton (4-6) vs. Donovan (15-6) |
| Regional 1 | Riverdale Patton def. Robbins Moody, 44-30 |
| Regional 2 | Donovan def. Hopkins Park Lorenzo Smith, 62-39 |
| Sectional 2 @ Saunemin |
| Mazon-Verona-Kinsman (14-9) vs. Pontiac St. Mary's (15-6) |
| Regional 3 | Mazon-Verona-Kinsman def. Morris Saratoga, 50-45 (2 OT) |
| Regional 4 | Pontiac St. Mary's def. Saunemin, 32-21 |
| Sectional 3 @ Wenona Fieldcrest East |
| Ottawa Wallace (22-0) vs. Toluca Fieldcrest West (18-2) |
| Regional 5 | Ottawa Wallace def. Mendota Holy Cross, 56-45 |
| Regional 6 | Toluca Fieldcrest West def. Wenona Fieldcrest East, 66-27 |
| Sectional 4 @ Cissna Park |
| Piper City Tri-Point (12-8) vs. Danville St. Paul (11-10) |
| Regional 7 | Piper City Tri-Point def. Crescent City, 33-21 |
| Regional 8 | Danville St. Paul def. Potomac, 40-35 |
| Sectional 5 @ Chrisman Scottland |
| Catlin (21-1) vs. Villa Grove (11-5) |
| Regional 9 | Catlin def. Chrisman Scottland, 33-11 |
| Regional 10 | Villa Grove def. Champaign St. Matthew, 37-34 |
| Sectional 6 @ Normal Epiphany |
| Mansfield Blue Ridge JHS (19-2) vs. Bloomington Holy Trinity (22-0) |
| Regional 11 | Mansfield Blue Ridge JHS def. LeRoy, 46-44 |
| Regional 12 | Bloomington Holy Trinity def. Normal Epiphany, 49-19 |
| Sectional 7 @ Hartsburg-Emden |
| Delavan (15-5) vs. Mt. Pulaski (14-7) |
| Regional 13 | Delavan def. South Pekin, 45-19 |
| Regional 14 | Mt. Pulaski def. Lincoln West Lincoln-Broadwell, 49-47 |
| Sectional 8 @ Peoria Pleasant Valley |
| Peoria Pleasant Valley (19-0) vs. Glasford Illini Bluffs (16-2) |
| Regional 15 | Peoria Pleasant Valley def. Peoria Christian, 49-28 |
| Regional 16 | Glasford Illini Bluffs def. Lewistown Central, 45-20 |
| Sectional 9 @ Abingdon |
| Abingdon (10-10) vs. Elmwood (14-7) |
| Regional 17 | Abingdon def. Joy Westmer, 18-16 |
| Regional 18 | Elmwood def. Bushnell-Prairie City, 50-35 |
| Sectional 10 @ Stewardson-Strasburg |
| Neoga (17-3) vs. Windsor (10-11) |
| Regional 19 | Neoga def. Stewardson-Strasburg, 44-37 |
| Regional 20 | Windsor def. Cerro Gordo, 31-23 |
| Sectional 11 @ Nokomis |
| Decatur Our Lady of Lourdes (17-4) vs. Raymond Lincolnwood (18-3) |
| Regional 21 | Decatur Our Lady of Lourdes def. Decatur Johns Hill, 45-33 |
| Regional 22 | Raymond Lincolnwood def. Nokomis JHS, 35-34 (2 OT) |
| Sectional 12 @ Divernon |
| Springfield Christ the King (15-5) vs. Springfield Calvary (13-8) |
| Regional 23 | Springfield Christ the King def. Springfield Blessed Sacrament, 38-21 |
| Regional 24 | Springfield Calvary def. Springfield St. Agnes, 40-38 |
| Sectional 13 @ Virginia |
| Jacksonville Our Saviour (18-4) vs. Winchester (20-3) |
| Regional 25 | Jacksonville Our Saviour def. Franklin, 40-34 |
| Regional 26 | Winchester def. Concord Triopia, 36-27 |
| Sectional 14 @ Mendon Unity |
| La Harpe (15-5) vs. Griggsville-Perry (16-5) |
| Regional 27 | La Harpe def. Carthage, 34-25 |
| Regional 28 | Griggsville-Perry def. Mt. Sterling Brown County, 37-34 |
| Sectional 15 @ Effingham Sacred Heart |
| Effingham St. Anthony (18-0) vs. Effingham Sacred Heart (13-6) |
| Regional 29 | Effingham St. Anthony def. Dieterich, 65-39 |
| Regional 30 | Effingham Sacred Heart def. Beecher City, 52-35 |
| Sectional 16 @ Mt. Olive |
| Lovejoy (9-12) vs. Carrollton St. John (8-13) |
| Regional 31 | Lovejoy def. Mt. Olive, 67-16 |
| Regional 32 | Carrollton St. John def. Greenfield, 42-30 |
