| Sectional 1 @ Lansing Memorial |
| Lansing Memorial vs. Markham Prairie-Hills (19-2) |
| Regional 1 | (Forfeited Game) |
| Regional 2 | Markham Prairie-Hills def. Country Club Hills Southwood, 48-8 |
| Sectional 2 @ Homer Glen Homer |
| Homer Glen Homer (15-4) vs. Bellwood Roosevelt (14-1) |
| Regional 3 | Homer Glen Homer def. Lockport Oak Prairie, 26-7 |
| Regional 4 | Bellwood Roosevelt def. Bolingbrook Jane Addams, 57-27 |
| Sectional 3 @ Manteno |
| Frankfort Hickory Creek (16-4) vs. Bradley Central (16-4) |
| Regional 5 | Frankfort Hickory Creek def. Beecher, 34-25 |
| Regional 6 | Bradley Central def. Manteno, 32-21 |
| Sectional 4 @ Mokena |
| New Lenox Martino (17-3) vs. Joliet Hufford (14-2) |
| Regional 7 | New Lenox Martino def. Mokena, 17-16 |
| Regional 8 | Joliet Hufford def. Minooka, 30-10 |
| Sectional 5 @ Coal City |
| Ottawa Shepherd (20-0) vs. Coal City (18-3) |
| Regional 9 | Ottawa Shepherd def. Streator Northlawn, 28-16 |
| Regional 10 | Coal City def. Pontiac JHS, 34-13 |
| Sectional 6 @ Forrest Prairie Central |
| Forrest Prairie Central (19-3) vs. Rantoul Eater (13-8) |
| Regional 11 | Forrest Prairie Central def. Watseka Glenn Raymond, 23-18 |
| Regional 12 | Rantoul Eater def. Mahomet-Seymour, 35-24 |
| Sectional 7 @ Normal Chiddix |
| Downs Tri-Valley vs. Normal Kingsley (20-0) |
| Regional 13 | Downs Tri-Valley def. Normal Chiddix, 25-20 |
| Regional 14 | Normal Kingsley def. Normal Parkside, 42-25 |
| Sectional 8 @ Morton JHS |
| Metamora Germantown Hills (15-4) vs. Dunlap MS (17-4) |
| Regional 15 | Metamora Germantown Hills def. Metamora St. Mary's, 27-16 |
| Regional 16 | Dunlap MS def. East Peoria Central, 37-27 |
| Sectional 9 @ Farmington Central |
| Canton Ingersoll (21-1) vs. Pekin Edison (12-6) |
| Regional 17 | Canton Ingersoll def. Macomb, 44-4 |
| Regional 18 | Pekin Edison def. Pekin Broadmoor, 36-35 (2 OT) |
| Sectional 10 @ TBD |
| Danville Oakwood (15-7) vs. Champaign Franklin (16-0) |
| Regional 19 | Danville Oakwood def. Westville JHS, 29-14 |
| Regional 20 | Champaign Franklin def. Tolono Unity, 38-34 |
| Sectional 11 @ Blue Mound Meridian |
| Blue Mound Meridian (14-8) vs. Mattoon (14-8) |
| Regional 21 | Blue Mound Meridian def. Decatur Jefferson, 29-27 |
| Regional 22 | Mattoon def. Pana JHS, 24-20 |
| Sectional 12 @ Rochester |
| Taylorville JHS (16-6) vs. Warrensburg-Latham (21-0) |
| Regional 23 | Taylorville JHS def. Rochester, 34-25 |
| Regional 24 | Warrensburg-Latham def. Maroa-Forsyth, 40-33 |
| Sectional 13 @ Carlinville |
| Piasa Southwestern (16-5) vs. Chatham Glenwood (14-4) |
| Regional 25 | Piasa Southwestern def. Carlinville, 34-32 ((OT)) |
| Regional 26 | Chatham Glenwood def. Springfield Grant, 28-27 |
| Sectional 14 @ Pittsfield Pikeland |
| Quincy vs. Pleasant Plains (18-3) |
| Regional 27 | Quincy def. Pittsfield Pikeland, 46-14 |
| Regional 28 | Pleasant Plains def. Petersburg PORTA JHS, 31-27 |
| Sectional 15 @ Toledo Cumberland |
| Toledo Cumberland (19-0) vs. Altamont |
| Regional 29 | Toledo Cumberland def. Teutopolis, 40-33 |
| Regional 30 | Altamont def. Lawrenceville Parkview, 44-40 |
| Sectional 16 @ Vandalia |
| Hillsboro (21-0) vs. Cahokia Wirth (19-3) |
| Regional 31 | Hillsboro def. Greenville, 51-36 |
| Regional 32 | Cahokia Wirth def. Edwardsville Liberty, 30-24 |
