| Sectional 1 @ Onarga Iroquois West |
| Riverdale Patton (6-7) vs. Buckley St. John's (10-8) |
| Regional 1 | Riverdale Patton def. St. Anne, 24-21 |
| Regional 2 | Buckley St. John's def. Piper City Tri-Point, 30-29 |
| Sectional 2 @ Morris Saratoga |
| Morris Saratoga (12-4) vs. Ottawa Wallace (14-7) |
| Regional 3 | Morris Saratoga def. Seneca, 18-4 |
| Regional 4 | Ottawa Wallace def. Cherry, 27-26 |
| Sectional 3 @ Streator St. Stephen |
| Streator St. Stephen (16-2) vs. Sparland Midland (18-2) |
| Regional 5 | Streator St. Stephen def. Grand Ridge, 49-30 |
| Regional 6 | Sparland Midland def. Toluca Fieldcrest West, 35-23 |
| Sectional 4 @ Bloomington Holy Trinity |
| Normal Epiphany (20-2) vs. Lexington (14-8) |
| Regional 7 | Normal Epiphany def. Normal Metcalf, 30-19 |
| Regional 8 | Lexington def. Pontiac St. Mary's, 28-22 |
| Sectional 5 @ Rantoul St. Malachy |
| Rantoul St. Malachy (13-9) vs. Bismarck-Henning (18-3) |
| Regional 9 | Rantoul St. Malachy def. Gifford, 18-15 |
| Regional 10 | Bismarck-Henning def. Cissna Park, 30-24 |
| Sectional 6 @ Chrisman Scottland |
| Paris Crestwood (18-3) vs. Sidell Jamaica (17-3) |
| Regional 11 | Paris Crestwood def. Chrisman Scottland, 33-28 |
| Regional 12 | Sidell Jamaica def. Catlin, 43-23 |
| Sectional 7 @ Tuscola East Prairie |
| Champaign St. Matthew (13-9) vs. Tuscola East Prairie (15-7) |
| Regional 13 | Champaign St. Matthew def. Champaign Holy Cross, 37-28 |
| Regional 14 | Tuscola East Prairie def. Cerro Gordo, 44-37 |
| Sectional 8 @ Mt. Pulaski |
| Mt. Pulaski (17-4) vs. Decatur Our Lady of Lourdes (9-4) |
| Regional 15 | Mt. Pulaski def. Argenta-Oreana, 52-47 (2 OT) |
| Regional 16 | Decatur Our Lady of Lourdes def. Pana Sacred Heart, 41-16 |
| Sectional 9 @ Brimfield |
| Brimfield (21-1) vs. Spring Bay Riverview (16-4) |
| Regional 17 | Brimfield def. Elmwood, 55-17 |
| Regional 18 | Spring Bay Riverview def. Peoria Limestone Walters, 19-11 |
| Sectional 10 @ Lewistown High School |
| Bartonville Monroe (14-7) vs. Lewistown Central (16-3) |
| Regional 19 | Bartonville Monroe def. Pekin Rankin, 27-24 |
| Regional 20 | Lewistown Central def. London Mills Valley, 36-22 |
| Sectional 11 @ Hamilton |
| Warsaw (17-4) vs. Colchester West Prairie (16-2) |
| Regional 21 | Warsaw def. Carthage, 46-38 |
| Regional 22 | Colchester West Prairie def. Abingdon, 31-23 |
| Sectional 12 @ Effingham St. Anthony |
| Sigel St. Michael's (13-8) vs. Palestine (10-2) |
| Regional 23 | Sigel St. Michael's def. Findlay Okaw Valley, 24-18 |
| Regional 24 | Palestine def. Effingham St. Anthony, 29-22 |
| Sectional 13 @ Nokomis JHS |
| Nokomis JHS (13-8) vs. Brownstown (16-5) |
| Regional 25 | Nokomis JHS def. Beecher City, 30-23 |
| Regional 26 | Brownstown def. Louisville North Clay, 31-23 |
| Sectional 14 @ Springfield Christ the King |
| Divernon (10-6) vs. Springfield St. Agnes (21-1) |
| Regional 27 | Divernon def. Pawnee, 26-15 |
| Regional 28 | Springfield St. Agnes def. Springfield St. Aloysius, 49-31 |
| Sectional 15 @ Jacksonville Our Saviour |
| Jacksonville Our Saviour (20-1) vs. Griggsville-Perry (15-7) |
| Regional 29 | Jacksonville Our Saviour def. Virginia, 33-32 |
| Regional 30 | Griggsville-Perry def. Mt. Sterling St. Mary, 22-10 |
| Sectional 16 @ Mt. Olive |
| Bunker Hill Meissner (19-1) vs. Hardin Calhoun (17-4) |
| Regional 31 | Bunker Hill Meissner def. East St. Louis Jackson, 50-30 |
| Regional 32 | Hardin Calhoun def. Winchester, 30-28 |
