| Sectional 1 @ Onarga Iroquois West |
| Thornton Wolcott (14-1) vs. Crescent City (5-10) |
| Regional 1 | Thornton Wolcott def. St. Anne, 24-16 |
| Regional 2 | Crescent City def. Donovan, 37-23 |
| Sectional 2 @ Seneca GS |
| Seneca (12-9) vs. Ottawa Wallace (17-4) |
| Regional 3 | Seneca def. Gardner, 27-24 ((OT)) |
| Regional 4 | Ottawa Wallace def. Cherry, 22-8 |
| Sectional 3 @ Roanoke-Benson |
| Toluca Fieldcrest West (19-1) vs. Grand Ridge (9-7) |
| Regional 5 | Toluca Fieldcrest West def. Sparland Midland, 34-12 |
| Regional 6 | Grand Ridge def. Ransom, 20-12 |
| Sectional 4 @ Normal Epiphany |
| Normal Epiphany (22-0) vs. Lexington (16-7) |
| Regional 7 | Normal Epiphany def. Colfax Ridgeview, 26-7 |
| Regional 8 | Lexington def. Pontiac St. Mary's, 38-32 |
| Sectional 5 @ Fisher |
| Fisher (8-9) vs. Royal Prairieview (15-4) |
| Regional 9 | Fisher def. Gifford, 15-12 |
| Regional 10 | Royal Prairieview def. Rossville-Alvin, 43-19 |
| Sectional 6 @ Oakland Lake Crest |
| Paris Crestwood (15-6) vs. Catlin (17-2) |
| Regional 11 | Paris Crestwood def. Hume Shiloh, 30-27 |
| Regional 12 | Catlin def. Homer Heritage, 36-18 |
| Sectional 7 @ LeRoy Elementary |
| LeRoy (14-6) vs. Cerro Gordo (11-9) |
| Regional 13 | LeRoy def. Champaign Judah Christian, 28-22 |
| Regional 14 | Cerro Gordo def. Tuscola East Prairie, 30-20 |
| Sectional 8 @ New Holland-Middletown MS |
| Lincoln Carroll Catholic (11-4) vs. Pana Sacred Heart (15-1) |
| Regional 15 | Lincoln Carroll Catholic def. Lincoln West Lincoln-Broadwell, 22-14 |
| Regional 16 | Pana Sacred Heart def. Decatur Johns Hill, 35-30 |
| Sectional 9 @ Peoria Pleasant Valley |
| Peoria Pleasant Valley (15-5) vs. Washington St. Patrick (19-3) |
| Regional 17 | Peoria Pleasant Valley def. Brimfield, 40-21 |
| Regional 18 | Washington St. Patrick def. Peoria Limestone Walters, 32-7 |
| Sectional 10 @ Table Grove V.I.T. |
| Tremont vs. Table Grove VIT (16-0) |
| Regional 19 | Tremont def. Bartonville Monroe, 26- |
| Regional 20 | Table Grove VIT def. Glasford Illini Bluffs, 25-23 |
| Sectional 11 @ Hamilton |
| Carthage (17-5) vs. La Harpe (21-1) |
| Regional 21 | Carthage def. Hamilton, 40-20 |
| Regional 22 | La Harpe def. Abingdon, 28-25 |
| Sectional 12 @ Effingham Sacred Heart |
| Sigel St. Michael's (12-6) vs. Effingham St. Anthony (19-1) |
| Regional 23 | Sigel St. Michael's def. Findlay Okaw Valley, 35-12 |
| Regional 24 | Effingham St. Anthony def. Dieterich, 35-18 |
| Sectional 13 @ Nokomis JHS |
| Nokomis JHS (18-3) vs. Brownstown (14-4) |
| Regional 25 | Nokomis JHS def. Beecher City, 39-6 |
| Regional 26 | Brownstown def. Louisville North Clay, 48-13 |
| Sectional 14 @ Pawnee |
| Springfield Little Flower (4-7) vs. Springfield Blessed Sacrament (18-1) |
| Regional 27 | Springfield Little Flower def. Divernon, 33-28 |
| Regional 28 | Springfield Blessed Sacrament def. Springfield Christ the King, 40-39 |
| Sectional 15 @ Griggsville-Perry |
| Griggsville-Perry (16-1) vs. Jacksonville Our Saviour (17-0) |
| Regional 29 | Griggsville-Perry def. Mt. Sterling Brown County, 31-12 |
| Regional 30 | Jacksonville Our Saviour def. Chandlerville A-C Central, 46-23 |
| Sectional 16 @ Mt. Olive |
| East St. Louis Jackson (3-12) vs. Hardin St. Norbert (15-2) |
| Regional 31 | East St. Louis Jackson def. Bunker Hill Meissner, 24-22 |
| Regional 32 | Hardin St. Norbert def. Carrollton St. John, 18-16 |
