| Sectional 1 @ Joliet Laraway |
| Joliet Laraway (10-6) vs. Hopkins Park Lorenzo Smith (9-3) |
| Regional 1 | Joliet Laraway def. Thornton Wolcott, 52-35 |
| Regional 2 | Hopkins Park Lorenzo Smith def. Donovan, 50-20 |
| Sectional 2 @ Grand Ridge GS, Grand Ridge |
| Ottawa Wallace (19-3) vs. Pontiac St. Mary's (19-2) |
| Regional 3 | Ottawa Wallace def. Mendota Holy Cross, 54-30 |
| Regional 4 | Pontiac St. Mary's def. Saunemin, 47-19 |
| Sectional 3 @ Roanoke-Benson JHS, Benson |
| Toluca Fieldcrest West (20-2) vs. Metamora St. Mary's (18-3) |
| Regional 5 | Toluca Fieldcrest West def. Wenona Fieldcrest East, 40-23 |
| Regional 6 | Metamora St. Mary's def. Lowpoint-Washburn, 48-23 |
| Sectional 4 @ Pleasant Valley MS, Peoria |
| Peoria Christian (13-10) vs. Elmwood (19-2) |
| Regional 7 | Peoria Christian def. Pekin Rankin, 44-42 |
| Regional 8 | Elmwood def. Peoria Pleasant Valley, 50-38 |
| Sectional 5 @ TBD |
| Biggsville Union (12-10) vs. La Harpe (19-0) |
| Regional 9 | Biggsville Union def. Woodhull AlWood, 36-32 |
| Regional 10 | La Harpe def. Cuba, 45-28 |
| Sectional 6 @ Fisher JHS, Fisher |
| Cissna Park (15-5) vs. Fisher (13-8) |
| Regional 11 | Cissna Park def. Milford, 27-20 |
| Regional 12 | Fisher def. Rantoul St. Malachy, 45-29 |
| Sectional 7 @ Bloomington Holy Trinity |
| Bloomington Holy Trinity (15-7) vs. Delavan (8-12) |
| Regional 13 | Bloomington Holy Trinity def. LeRoy, 45-23 |
| Regional 14 | Delavan def. Hartsburg-Emden, 40-21 |
| Sectional 8 @ Shiloh GS, Hume |
| Catlin (20-2) vs. Chrisman Scottland (19-1) |
| Regional 15 | Catlin def. Ogden, 44-43 |
| Regional 16 | Chrisman Scottland def. Kansas, 51-18 |
| Sectional 9 @ Champaign Holy Cross |
| Champaign Holy Cross (14-4) vs. Cerro Gordo (19-3) |
| Regional 17 | Champaign Holy Cross def. Champaign St. Matthew, 38-26 |
| Regional 18 | Cerro Gordo def. Arcola, 37-21 |
| Sectional 10 @ Pawnee GS, Pawnee |
| Decatur Our Lady of Lourdes (13-9) vs. Raymond Lincolnwood (18-3) |
| Regional 19 | Decatur Our Lady of Lourdes def. Buffalo Tri-City, 37-22 |
| Regional 20 | Raymond Lincolnwood def. Pawnee, 39-32 |
| Sectional 11 @ Calvary Academy, Springfield |
| Lincoln West Lincoln-Broadwell (18-1) vs. Springfield Calvary (14-6) |
| Regional 21 | Lincoln West Lincoln-Broadwell def. Greenview, 71-31 |
| Regional 22 | Springfield Calvary def. Springfield St. Agnes, 46-41 |
| Sectional 12 @ A-C Central JHS, Chandlerville |
| Springfield Christ the King (17-3) vs. Winchester (19-3) |
| Regional 23 | Springfield Christ the King def. Waverly, 42-13 |
| Regional 24 | Winchester def. Concord Triopia, 34-18 |
| Sectional 13 @ Brown County MS, Mt. Sterling |
| Carthage (19-2) vs. Payson Seymour (21-2) |
| Regional 25 | Carthage def. Nauvoo-Colusa, 40-24 |
| Regional 26 | Payson Seymour def. Barry, 27-23 |
| Sectional 14 @ Sacred Heart GS, Effingham |
| Martinsville (6-11) vs. Effingham St. Anthony (16-3) |
| Regional 27 | Martinsville def. Oblong, 49-37 |
| Regional 28 | Effingham St. Anthony def. Dieterich, 34-30 |
| Sectional 15 @ Ramsey |
| Findlay Okaw Valley (15-7) vs. Nokomis JHS (12-8) |
| Regional 29 | Findlay Okaw Valley def. St. Elmo, 25-22 |
| Regional 30 | Nokomis JHS def. Pocahontas, 45-29 |
| Sectional 16 @ St. John the Evangelist, Carrollton |
| Pleasant Hill (13-7) vs. Madison (14-6) |
| Regional 31 | Pleasant Hill def. Palmyra Northwestern, 33-28 |
| Regional 32 | Madison def. Jerseyville St. Francis HG |
