| Sectional 1 @ Donovan |
| Chicago St. Malachy (19-4) vs. Hopkins Park Lorenzo Smith (12-1) |
| Regional 1 | Chicago St. Malachy def. Crest Hill Richland, 59-44 |
| Regional 2 | Hopkins Park Lorenzo Smith def. Donovan, 35-20 |
| Sectional 2 @ Grand Ridge |
| Gardner (16-4) vs. Wenona Fieldcrest East (16-6) |
| Regional 3 | Gardner def. Mazon-Verona-Kinsman, 36-32 |
| Regional 4 | Wenona Fieldcrest East def. Tonica, 38-25 |
| Sectional 3 @ Fisher |
| Cissna Park vs. Fisher (14-7) |
| Regional 5 | Cissna Park def. Rossville-Alvin, 36-27 |
| Regional 6 | Fisher def. Royal Prairieview, 38-30 |
| Sectional 4 @ Cornell |
| Lexington vs. Roanoke-Benson (19-3) |
| Regional 7 | Lexington def. Colfax Ridgeview, 39-29 |
| Regional 8 | Roanoke-Benson def. Toluca Fieldcrest West, 25-21 |
| Sectional 5 @ Delavan |
| Peoria Pleasant Valley (15-6) vs. Delavan (14-6) |
| Regional 9 | Peoria Pleasant Valley def. Bartonville Monroe, 58-27 |
| Regional 10 | Delavan def. Spring Bay Riverview, 41-28 |
| Sectional 6 @ Brimfield |
| Elmwood (18-3) vs. Table Grove VIT |
| Regional 11 | Elmwood def. Yates City, 48-39 |
| Regional 12 | Table Grove VIT def. Hanna City Logan, 43-35 |
| Sectional 7 @ Biggsville Union |
| Monmouth ICS (13-9) vs. Hamilton (16-3) |
| Regional 13 | Monmouth ICS def. Woodhull AlWood, 41-23 |
| Regional 14 | Hamilton def. Nauvoo-Colusa, 44-24 |
| Sectional 8 @ Hume Shiloh |
| Philo St. Thomas (18-2) vs. Martinsville (7-12) |
| Regional 15 | Philo St. Thomas def. Champaign Holy Cross, 38-31 |
| Regional 16 | Martinsville def. Oakland Lake Crest, 24-23 |
| Sectional 9 @ Buffalo Tri-City |
| Cerro Gordo (11-9) vs. Springfield St. Aloysius (9-12) |
| Regional 17 | Cerro Gordo def. Decatur Our Lady of Lourdes, 45-30 |
| Regional 18 | Springfield St. Aloysius def. Kincaid South Fork, 43-29 |
| Sectional 10 @ Normal Epiphany |
| Bloomington Holy Trinity vs. Lincoln Carroll Catholic (19-3) |
| Regional 19 | Bloomington Holy Trinity def. Normal Metcalf, 50-44 |
| Regional 20 | Lincoln Carroll Catholic def. Lincoln West Lincoln-Broadwell, 39-35 |
| Sectional 11 @ Virginia |
| Springfield Christ the King (19-0) vs. Jacksonville Our Saviour (15-8) |
| Regional 21 | Springfield Christ the King def. Springfield Calvary, 43-27 |
| Regional 22 | Jacksonville Our Saviour def. Virginia, 28-24 |
| Sectional 12 @ Payson Seymour |
| Bowen Southeastern (21-1) vs. Griggsville-Perry (19-3) |
| Regional 23 | Bowen Southeastern def. Mt. Sterling Brown County, 50-29 |
| Regional 24 | Griggsville-Perry def. Winchester, 39-20 |
| Sectional 13 @ Effingham St. Anthony |
| Newton St. Thomas (16-1) vs. Effingham St. Anthony (13-6) |
| Regional 25 | Newton St. Thomas def. Dieterich, 36-23 |
| Regional 26 | Effingham St. Anthony def. Sigel St. Michael's, 32-22 |
| Sectional 14 @ Lovington |
| Lovington (19-2) vs. Nokomis JHS (13-5) |
| Regional 27 | Lovington def. Arcola, 41-31 |
| Regional 28 | Nokomis JHS def. Cowden-Herrick, 39-36 |
| Sectional 15 @ Carrollton St. John |
| Raymond Lincolnwood vs. Carrollton St. John (20-0) |
| Regional 29 | Raymond Lincolnwood def. Waverly, 25-24 |
| Regional 30 | Carrollton St. John def. Greenfield, 37-14 |
| Sectional 16 @ Mulberry Grove |
| Mulberry Grove GS vs. Lovejoy (5-8) |
| Regional 31 | Mulberry Grove GS def. Mt. Olive, 37-21 |
| Regional 32 | Lovejoy def. Madison, 55-47 |
