| Sectional 1 @ Harvey Brooks |
| Harvey Brooks (11-1) vs. Country Club Hills Southwood (15-2) |
| Regional 1 | Harvey Brooks def. Lansing Memorial, 41-17 |
| Regional 2 | Country Club Hills Southwood def. Markham Prairie-Hills, 36-9 |
| Sectional 2 @ Bolingbrook Jane Addams |
| Bolingbrook Brooks (19-2) vs. Shorewood Troy (18-1) |
| Regional 3 | Bolingbrook Brooks def. Bolingbrook Jane Addams, 43-28 |
| Regional 4 | Shorewood Troy def. Lockport Oak Prairie, 37-14 |
| Sectional 3 @ Manteno |
| Peotone (17-4) vs. Bradley Central (17-3) |
| Regional 5 | Peotone def. Frankfort Hickory Creek, 30-5 |
| Regional 6 | Bradley Central def. Momence JHS, 29-26 |
| Sectional 4 @ Mokena |
| Mokena (20-0) vs. Minooka |
| Regional 7 | Mokena def. New Lenox Martino, 31-16 |
| Sectional 5 @ Pontiac JHS |
| Peru Washington (15-4) vs. Pontiac JHS (17-4) |
| Regional 9 | Peru Washington def. Ottawa Shepherd, 30-21 |
| Regional 10 | Pontiac JHS def. Dwight, 20-16 |
| Sectional 6 @ Paxton-Buckley-Loda |
| Mahomet-Seymour (15-6) vs. Forrest Prairie Central (19-3) |
| Regional 11 | Mahomet-Seymour def. Rantoul Eater, 24-16 |
| Regional 12 | Forrest Prairie Central def. Herscher Limestone, 35-4 |
| Sectional 7 @ Normal Chiddix |
| Downs Tri-Valley vs. Normal Parkside (18-2) |
| Regional 13 | Downs Tri-Valley def. Bloomington JHS, 30-23 |
| Regional 14 | Normal Parkside def. Normal Kingsley, 29-19 |
| Sectional 8 @ Washington MS |
| Washington MS (20-0) vs. East Peoria Central (18-2) |
| Regional 15 | Washington MS def. Metamora Germantown Hills, 29-16 |
| Regional 16 | East Peoria Central def. Mossville, 38-25 |
| Sectional 9 @ Green Valley Midwest Central |
| Havana (20-1) vs. Macomb |
| Regional 17 | Havana def. Easton Illini Central, 41-27 |
| Regional 18 | Macomb def. Bushnell-Prairie City, 28-22 |
| Sectional 10 @ Danville South View |
| Danville South View (15-3) vs. St. Joseph (21-0) |
| Regional 19 | Danville South View def. Georgetown Mary Miller, 23-8 |
| Regional 20 | St. Joseph def. Tolono Unity, 40-31 |
| Sectional 11 @ Monticello |
| Monticello (19-2) vs. Mattoon (17-3) |
| Regional 21 | Monticello def. Mt. Zion, 30-7 |
| Regional 22 | Mattoon def. Assumption Central A & M, 30-22 |
| Sectional 12 @ Riverton |
| Rochester (15-7) vs. Warrensburg-Latham (20-1) |
| Regional 23 | Rochester def. Taylorville JHS, 16-9 |
| Regional 24 | Warrensburg-Latham def. Illiopolis Sangamon Valley, 24-13 |
| Sectional 13 @ Carlinville |
| Carlinville (21-1) vs. Springfield Franklin (16-0) |
| Regional 25 | Carlinville def. Piasa Southwestern, 36-15 |
| Regional 26 | Springfield Franklin def. Chatham Glenwood, 25-23 |
| Sectional 14 @ Pittsfield Pikeland |
| Liberty vs. Petersburg PORTA JHS (18-2) |
| Regional 27 | Liberty def. Camp Point Central, 38-28 |
| Regional 28 | Petersburg PORTA JHS def. Jacksonville Turner, 32-18 |
| Sectional 15 @ Casey-Westfield |
| Teutopolis (19-1) vs. Effingham JHS (10-11) |
| Regional 29 | Teutopolis def. Paris Mayo, 36-12 |
| Regional 30 | Effingham JHS def. Sumner Red Hill, 24-15 |
| Sectional 16 @ Vandalia |
| Litchfield (15-6) vs. Edwardsville Liberty (14-2) |
| Regional 31 | Litchfield def. Hillsboro, 35-23 |
| Regional 32 | Edwardsville Liberty def. Cahokia Wirth, 44-24 |
